Abstract
Desmoplastic fibroblastoma is a rare benign neoplasm of the oral cavity usually found in subcutaneous and muscle tissue. The literature reports only seven cases. Woman, 20, had an asymptomatic nodular lesion of the right buccal mucosa measuring about 2.5 cm. It showed evidence of submucosal implantation and rubbery consistency. The preliminary diagnosis was dermal cyst. An excisional biopsy was done, and microscopy revealed benign mesenchymal neoplasm hypocellularized with scant fibroblasts of varying formats immersed in a highly collagenous stroma and with a light inflammatory infiltrate peripherally. Immunohistochemical analysis was positive for AML, factor XIIIa, and CD68 but negative for S-100. The histopathological diagnosis was desmoplastic fibroblastoma. The patient has been disease-free for 8 months with no sign of recurrence. The development of this rare lesion in the oral cavity demonstrates the need to carefully formulate a correct diagnosis leading to appropriate treatment.
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