Abstract
Collagenous fibroma, also known as desmoplastic fibroblastoma, is a rare benign slow growing tumor particularly uncommon in the oral cavity. The aim of this study was to analyze the clinical and histopathological features of an oral collagenous fibroma as well as to compare this data with those reported in an English-literature review. The thirteenth case of collagenous fibroma in the oral cavity and the first to present clinically as a bilateral mass was described. A 48-years-old female patient was referred to a School of Dentistry, complaining about an asymptomatic swelling on the hard palate, lasting around ten years. The intraoral examination revealed two well-defined mass, bilaterally in the hard palate. An excisional biopsy was performed. Microscopically, the connective tissue consisted of dense collagen bundles in which were seen scarcely distributed spindle-shaped to stellate fibroblastic cells. Blood vessels were few, as well as inflammatory cells. Immunohistochemical staining was positive for vimentin, α-smooth muscle actin and factor XIIIa and negative for S-100, CD68, CD34, HHF35, desmin and AE1/AE3. The patient remains disease-free 24 months after excision. In conclusion, oral collagenous fibroma should be included in the differential diagnosis of bilateral sessile nodules in the oral cavity. Key words:Connective tissue, mouth diseases, mouth neoplasms, oral diagnosis, oral pathology.
Highlights
Collagenous fibroma (CF), known as desmoplastic fibroblastoma, is a rare benign slow growing tumor, first described by Evans in 1995 [1]
CF is a rare tumor in the oral cavity and, to date, no intraoral bilateral case of this lesion was reported [1,8]
Considering the twelve cases of oral CF published in English-language literature (Table 1), eight of them (75%) occurred in female, revealing a higher prevalence between women, as opposed to extraoral cases when the injury occurs mainly in males [1,3]
Summary
Collagenous fibroma (CF), known as desmoplastic fibroblastoma, is a rare benign slow growing tumor, first described by Evans in 1995 [1]. The lesion, is rare in the oral cavity [3,4,5,6,7,8,9,10,11,12,13]. CF is relatively paucicellular with spindle to stellate-shaped fibroblasts and myofibroblasts cells embedded in an abundant collagenous background. Few cases of CF affecting the intraoral region were reported in English-language literature [3,4,5,6,7,8,9,10,11,12,13,14]. The aim of this article is to present the first case of bilateral CF in the oral cavity, discussing its clinical and histological characteristics with data from a literature review
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