Abstract
Desmosomes are macromolecular cell-cell junctions critical for maintaining adhesion and resisting mechanical stress in the heart and epithelial tissue. Dysregulation of desmosomal proteins and desmosome function occurs in genetic and acquired diseases of the heart and skin and is implicated in cancer progression, highlighting the important role these junctions play. Desmosomes have a complex architecture, containing transmembrane cadherins and cytosolic plaque proteins. Desmoplakin is an essential desmosome protein which links the desmosomal plaque to the intermediate filament cytoskeleton.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
