Abstract
AbstractUnder phosphine catalysis facilitated through desilylation, intramolecular annulation/nucleophilic addition of trimethylsilylethynyl benzoxazinanones with electron‐deficient imines or alkenes was achieved to afford a series of indole derivatives in moderate to high yields. The trimethylsilylethynyl benzoxazinanones without electron‐withdrawing group on the alkyne moiety functioned as phosphine acceptors. Notably, the distinctive desilylation activation played a key role in catalytic process. Particularly, those indole derivatives could be readily transformed into various biologically significant γ‐carboline compounds. The use of chiral phosphine achieved asymmetric reaction, leading to a 95% ee of product.
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