Abstract
AbstractA series of new aspartic and glutamic acid based peptide dendrons and dendrimers were designed and synthesized. The supramolecular assembly of these novel molecules were studied by scanning electron microscopy (SEM), atomic force microscopy (AFM), and attenuated total reflectance Fourier transform infrared (ATR‐FTIR) spectroscopy. The dendrons and dendrimers formed gel in aqueous or in organic phase with excellent storage modulus as measured by rheometry. Glutamic acid‐based higher generation dendrons and dendrimers showed a minimum gelation concentration as low as 1 wt/v (%) in CHCl3. Interestingly, the higher generation dendrimers 5 d, 6 d, and 7 d gelated even polar solvent DMSO. The lipidated peptide dendrons showed thermotropic liquid crystalline behavior with the formation of columnar and smectic phase as confirmed by differential scanning calorimetry (DSC) and polarization optical microscopy (POM). These lipidated peptides exhibited well‐ordered specific modes of self‐assembly and hence could be exploited for several applications such as drug delivery vehicles and in tissue engineering.
Published Version
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