Abstract
AbstractA simple and efficient methodology has been designed to synthesize a series of versatile and novel coumarin based scaffolds displaying several alkyl, halogen, and alkoxy groups from 4‐Bromomethylcoumarins and pre‐functionalized phenol. The title compounds have been evaluated for their in‐vitroanti‐microbial and anti‐inflammatory activity. Physiological properties like lipophilicity and IC50 value have also been calculated. To support the in vitro results, computational experiments were carried out to analyze probable binding modes. The interactions between substituted coumarins and bovine protein showed promising activity with higher C‐score values.
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