DESIGN, SYNTHESIS AND BIOLOGICAL PROPERTIES OF TRANSITION METAL COMPLEXES OF SCHIFF BASE LIGAND DERIVED FROM PYRIDINE DERIVATIVES

Abstract

Novel classes of heterocyclic Schiff base ligand were prepared from the condensation of 2-methoxy benzaldehyde and 2-amino 4-methyl pyridine in absolute ethanol in presence of catalytic amount of dilute HCl. The resulted novel class ofheterocyclic ligand was treated with metal salt or acetate results in the formation of Fe (III), Co (III), Ni (II) & Cu (II)complexes. All newly synthesized resulted ligand its metal complexes were characterized by elemental analysis and FTIR,Magnetic susceptibility, Antimicrobial, Antioxidant, ESR spectrum for Copper complex in DMF solvent recorded atroom temperature. The Electronic spectra and magnetic susceptibility measurements indicates that square planer andoctahedral geometry of these complexes also suggest their structure in which (N, O) group acts as bidentate ligand. Thethermal stability, decomposition behavior has been investigated by using thermo gravimetric analysis at heating rate 10°Cper minute with nitrogen atmosphere and their and kinetic parameter was also calculated by using Freeman Carrollmethod. Screening results of antimicrobial, antioxidant activity of transition metal complexes shows good antibacterialand antifungal activity and excellent antioxidant activity.