Design, synthesis and biological evaluation of heterocyclic methyl substituted pyridine Schiff base transition metal complexes

Jitendra N Borase,Dhanraj S Shirsath,S S Rajput,R G Mahale

doi:10.1007/s42452-021-04144-z

Abstract

In recent years heterocyclic Schiff base metal complexes attract more attention in biological application and also showing interesting co-ordination chemistry. In this research article a novel heterocyclic methyl-substituted pyridine Schiff base transition metal complexes of Fe(III), Co(III), Cu(II), and Ni(II) have been design and synthesized by reacting metal acetate or metal salts (FeCl3, CoOAc, CuOAc, NiOAc), with substituted heterocyclic ligand. All newly synthesized metalcomplexes were characterized by spectroscopic data and screened for elemental analysis, FT-IR, ESR, Magnetic susceptibility and TGA. The Electronic spectra and magnetic susceptibility measurements indicates that square planer and octahedral geometry of these complexes also suggest their structure in which (N, O) group acts as bidentate ligand. The thermal stability, decomposition rate and thermodynamic parameters of synthesized metal complexes were calculated by Freeman Carroll method. Also the biostatistical data of antimicrobial and anti-oxidant activities of synthesized metal complexes indicates moderate to good results.Graphic abstract

Highlights

A large number of heterocyclic Schiff base ligand and their transition metal complexes have been dynamically investigated fortheir biological application, thermal analysis, spectral analysis and for their interesting coordination chemistry such as Cu(II), Co(II), Ni(II), Zn(II) and Ru(II)complexes with the Schiff base ligand derived from 5-amino-4H-1,2,4-triazole-3-thiol and 3-hydroxy4-methoxybenzaldehyde, benzothiazoleimino-benzoic acid ligands and their Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes
Synthesis of bidentatetriazole ligand and its monomeric metal complexes in the company relating to Cd(II), Co(II), Fe(III), Cu(II), and Ni(II) ions is demonstrated and their antibacterial study relating to Ni(II), Cu(II), Fe(III), Cd(II), and Co(II) complexes of 4-amino5-stearyl-1,2,4-triazole-3-thiol[1,2,3,4]
Schiff base ligands are synthesized from condensation of aliphatic or aromatic aldehyde with primary aliphatic or aromatic amine in ethanolic solvent the reaction is accelerated by adding the catalytic amount of acid [5]

Summary

Introduction

A large number of heterocyclic Schiff base ligand and their transition metal complexes have been dynamically investigated fortheir biological application, thermal analysis, spectral analysis and for their interesting coordination chemistry such as Cu(II), Co(II), Ni(II), Zn(II) and Ru(II)complexes with the Schiff base ligand derived from 5-amino-4H-1,2,4-triazole-3-thiol and 3-hydroxy4-methoxybenzaldehyde, benzothiazoleimino-benzoic acid ligands and their Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes. The common structural feature of these compounds is the azomethine group with a general formula (R–CH = N–R,) Where R is any alkyl group which may be variously substituted. These compounds are known as anils, imines, azomethine [6]. Schiff base are well known for their wide application and are useful intermediates in organic synthesis [7] These compound has intrinsic biological activities, including anticancer [8], antitumor [9], antitubercular [10], antibacterial [11], antifungal and antifertility [12], herbicidal [13], antioxidant [14], antiproliferative [15], activities. Schiff bases exhibit fluorescence [16], photoluminescence [17] and potentiometric titration [18], aggregation [19] and anthelmintic activities [20]

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Discussion

Conclusion