Abstract
A novel series of thiourea, carbamimidothioic acid, 4, 5dihydrooxazole2thiol, oxazolidine2 thine, and 2amino1phenylpropyl2chloroacetate derivatives was designed and synthesized using 2amino1phenylpropan1ol (Lnorephedrine) as a strategic starting material. The structures of the newly synthesized compounds were established by elemental analyses, IR, and 1 H NMR and 13C NMR spectral data. The compounds were evaluated for their in vitro anticancer activity against various cancer cell lines. The corresponding acetamide, carbamimidothioic acid, and 22amino1phenylpropyl2chloroacetate deriv atives showed almost the same activity as the standard drug doxorubicin against human breast cancer cell line (MCF7). Also, the acetamide and 2thioxoimidazolidin4one derivatives exhibited higher activity than the reference drug doxorubicin against human colon cancer cell line (HCT 116).
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