Abstract
A library of arylketoalkyne derivatives of 7-azaindole ( 10a-j ) have been designed and prepared in good yields via Sonogashira cross coupling of 4-(3,4,5-Trimethoxyphenyl)-3-(oxazol-5-yl)-1-(prop‑2-ynyl)-1H-pyrrolo[2,3- b ]pyridine ( 8 ) with different types of aryl acid chlorides ( 9a-j ) in the presence of PdCl 2 (PPh 3 ) 2 and their structure confirmed by 1 HNMR, 13 CNMR and mass spectral data. Further, all the compounds were examined for their anticancer activity towards four human cancer cell lines such as MCF-7 (beast), A549 (lung), Colo-205 (colon) and A2780 (ovarian) and etoposide used as positive control. Among them, compounds 10b, 10c, 10d, 10f and 10 g showed more promising activity on selected cancer cell lines.
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