Abstract
A series of 8‐methoxyl ciprofloxacin (8‐OMe CPFX)‐isatin hybrids 3a–f and 4a–f tethered through propylene were designed, synthesized, and examined for their in vitro antibacterial activities against a panel of Gram‐positive and Gram‐negative pathogens including drug‐resistant bacteria. All the synthesized hybrids (minimum inhibitory concentration: ≤0.03–64 μg/mL) exhibited considerable activities against the tested strains, especially against the Gram‐negative pathogens. Among them, hybrid 3b was no inferior to the parent 8‐OMe CPFX that could act as a starting point for further optimization.
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