Design, structural and spectroscopic elucidation, and the in vitro biological activities of new triorganotin dithiocarbamates – Part II

Abstract

The two novel dithiocarbamate salts, [Na{S2CNR(R1)}] (i), [Na{S2CNR(R2)}] (ii), R=methyl, R1=CH2CH(OMe)2, R2=2-methyl-1,3-dioxolane, previously synthesized by us, have been used in chemical reactions with triorganotin halides. Hence, five new complexes: [SnPh3{S2CNR(R1)}] (1), [SnCy3{S2CNR(R1)}] (2), [SnMe3{S2CNR(R2)}] (3), [SnPh3{S2CNR(R2)}] (4) and [SnCy3{S2CNR(R2)}] (5), [R=methyl, R1=CH2CH(OMe)2, and R2=2-methyl-1,3-dioxolane], have been isolated. All compounds were authenticated in terms of infrared, 1H and 13C NMR, and the complexes were also characterized using 119Sn NMR, 119Sn Mössbauer and X-ray crystallography, in the case of complexes (1), (4) and (5). The biological activity of all derivatives has been screened in terms of IC90 (μmolL−1) and IC50 (μmolL−1) against Aspergillus flavus, Aspergillus niger, Aspergillus parasiticus and Penicillium citrinum, and the results correlated well with a performed study of structure–activity relationship (SAR). Complexes (1) and (4) displayed nanomolar inhibition concentration in terms of IC50.