Synthesis, characterization and antifungal activity of new dithiocarbamate-based complexes of Ni(II), Pd(II) and Pt(II)

Abstract

We describe in this work the syntheses, characterization and antifungal activity of the complexes: [Ni{S2CNMe(R1)}2] (1), [Pd{S2CNMe(R1)}2] (2), [Pt{S2CNMe(R1)}2] (3), [Ni{S2CNMe(R2)}2] (4), [Pd{S2CNMe(R2)}2] (5), [Pt{S2CNMe(R2)}2] (6), {R1=CH2CH(OMe)2 and R2=2-methyl-1,3-dioxolane}. Complexes (1)–(6) have been characterized by IR and 1H and 13C NMR spectroscopy. In addition, the structures of (1), (2) and (3) have been authenticated by X-ray diffraction. The antifungal activities of (1)–(6) have been screened against Aspergillus flavus, Aspergillus niger, Aspergillus parasiticus and Penicillium citrinum and the results, in the form of the minimum inhibition concentration (MIC), and compared with those of nystatin and miconazole nitrate, used as control drugs. All complexes had greater activity than nystatin. Palladium containing complexes, (2) and (5), were the more active against A. flavus. The growth of A. niger, were more efficiently affected by Ni(II) complexes (1) and (4) and complex (6) was effective in reducing the colonies of A. parasiticus.