Design strategies of logic gate sensors based on FRET mechanism

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Chemists can now use molecules to mimic the concepts and equipment of mathematics and computer science. Recently, there has been growth in the integration of logic gates onto tiny arrays. A selection of these situations’ fundamental design concepts was considered. For suitable distances for energy transfer, FRET (fluorescence resonance energy transfer) is widely used in logic gate design. The analysis of bio-active molecules with FRET method has become an appealing technique in the life sciences. However, the design strategy of logic gate sensors based on FRET mechanism has not been reviewed yet. In this review, examples include molecular computational identification of active objects based on FRET mechanism. These examples are classified according to the molecular logic gate which including small molecules and macromolecules, DNA-based logic gate, and nanoparticles-based logic gate. At last, the perspectives of the logic gate sensors based on FRET were proposed.