Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates

Abstract

In this article, we are reporting a series of di-and tri-organotin(IV) carboxylate complexes (1–4) derived from the reaction of sodium-3-bromophenylacetate (NaL) with (CH3)2SnCl2, (C4H9)2SnCl2, (CH3)3SnCl and (C4H9)3SnCl in dried toluene while refluxing for 8 h. The desired organotin(IV) derivative were analyzed by elemental analyzer, FTIR, NMR and single crystal XRD. The antimicrobial data against the tested bacterial strains follow the order: 2 > 4 > 3 > 1 > HL. The anticancer potential of the synthesized compounds was evaluated against the lung cancer cell line (A549) and normal lung fibroblast cell line (MRC-5) and it was observed that 4 was the highly cytotoxic against A549 while HL and 1 showed no cytotoxicity against MRC-5, neither at lower or higher concentrations.