DESIGN, OPTIMIZATION, AND EVALUATION OF RAFT FORMING GASTRO RETENTIVE DRUG DELIVERY SYSTEM OF LAFUTIDINE USINGBOX–BEHNKEN DESIGN

Lankalapalli Srinivas,Shanti Sagar

doi:10.22159/ijap.2022v14i1.43358

Lankalapalli Srinivas, Shanti Sagar

Open Access

https://doi.org/10.22159/ijap.2022v14i1.43358

Copy DOI

Abstract

Objective: The current research was aimed to formulate and evaluate raft forming gastro retentive floating drug delivery systems of Lafutidine for improving gastric residence time and sustained drug release for an extended time. Methods: Using Box–Behnken experimental design 17 formulations of lafutidine GRDDS were designed and evaluated for various parameters like physical appearance, pH, In vitro gelling study, in vitro buoyancy study, measurement of viscosity, density measurement, gel strength, drug content, acid neutralization capacity, the profile of neutralization, in vitro dissolution, release kinetic and stability studies. Results: All the evaluations were performed and observed that the values were within range, and the buoyancy lag time ranged within 14.76 to 25.84 sec and the formulations remained buoyant for more than 8h with the gelling time of 12h, the drug content was ranging from 98.96 to 99.55 %, and in vitro release was 86.86 to 99.34% by the end of 12h. The release kinetics followed zero-order with Higuchi’s model that indicating that drug release was found to be followed by the matrix diffusion process. Conclusion: Out of all formulations F3 was the optimized formulation and it was further characterized for FTIR, DSC, and stability studies, which exposed that there were no interactions amongst drug and excipients and no major change in the formulation and found to be stable.

Highlights

Oral administration is the preferred method of delivering drugs to the systemic circulation
All the formulations were evaluated for buoyancy lag time, percent drug release at 1hour, and percent drug release at the end of 12hour
The quadratic models generated show that factors A has a major effect followed by C and B have a significant influence on buoyancy lag time

Summary

Introduction

Oral administration is the preferred method of delivering drugs to the systemic circulation. Its convenience and flexibility have led to the increasing interest in the development of new drug delivery methods. The concept of a controlled release gastroretentive dosage form (GRDF) was developed to provide continuous distribution of formulation to the upper GI tract while minimizing the limitations of poor colon absorption. These dosage forms are designed to stay in the stomach for an extended amount of time while releasing their contents in a steady and controlled manner. The gastroretentive drug delivery system (GRDD) stays in the stomach for a long time to improve drug bioavailability. Bio-adhesive, expansion, magnetic, and floating ion exchange resins and raft forming systems are all examples of GRDD [1]

Methods

Results

Conclusion