Abstract
Objective: The main aim is to design, optimize, and evaluate ibuprofen fast-dissolving tablets by employing starch valerate-A novel super disintegrant.
 Methods: The fast-dissolving tablet of ibuprofen was prepared by employing starch valerate as super disintegrant in different proportions in each case by direct compression method using 23 factorial design, sodium starch glycolate, and crospovidone used as super disintegrants. In the 23 factorial design, these super disintegrants were applied to investigate the interaction effects of three variables, that is, (a) starch valerate, (b) sodium starch glycolate, and (c) crospovidone. The drug content, hardness, friability, disintegration time, and other dissolution characteristics were determined.
 Results: The starch valerate prepared was found to be fine, free-flowing, slightly crystalline powder. Starch xanthate exhibited good swelling in water with 125.2%. All the fast-dissolving tablets formulated employing starch valerate were of good quality with regard to drug content (100±5%), hardness (3.6–3.8 kg/sq. cm), and friability (0.11-0.12%). The disintegration time of all the formulated tablets was found to be in the range of 12±0.02 to 30±0.02s. The optimized formulation FL8 has the least disintegration time, that is, 12±0. 02s. The in vitro wetting time of the formulated tablets was found to be in the range of 21±0.09 to 44±0.10s. The in-vitro wetting time was less (i.e., 90s) in optimized formulation FL8. The water absorption ratio of the formulated tablets was found to be in the range of 30±0.12 to 100±0.09%.
 Conclusion: Starch valerate was found to be a super disintegrant which enhanced the dissolution efficiency when combined with sodium starch glycolate, crospovidone, with the ibuprofen.
Highlights
Tablets play a major role in the development of various dosage forms in the drug delivery system because these can be manufactured adequate dosing can be done, stability, and easy to handle
The prepared starch valerate was found to be fine, amorphous, and free-flowing powder. It is insoluble in water, aqueous buffers and in organic solvents which were tested with 1% w/v of starch valerate dispersion
The presence of peaks absorption at 1639.97 cm−1, which is a characteristic peak of ester, so from FTIR studies, it was concluded that starch valerate was formed when starch was allowed to react with valeric acid
Summary
Tablets play a major role in the development of various dosage forms in the drug delivery system because these can be manufactured adequate dosing can be done, stability, and easy to handle. Fastdissolving tablets are the dosage forms that disintegrate fastly to release the drug and dissolve in the saliva, further the drug gets absorbed from the pharynx to different sections of gastrointestinal tract. These fast-dissolving dosage forms show greater bioavailability than that of conventional dosage forms and it has become a substitute dosage form to geriatrics, pediatrics, and to those who are bedridden, mentally unwell, fear of swallowing, and these FDTs provide greater patient compliance as there is no requirement of water and shows faster therapeutic action
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