Design of monodispersed PVP functionalized biocompatible manganese ferrite nanoparticles for hyperthermia application

Abstract

Magnetic nanoparticles which can be triggered externally by an alternating current magnetic field (AMF) have shown their potential for various biomedical applications. Magnetic hyperthermia using magnetic nanoparticles (MNPs) has emerged as a promising treatment for cancer. For effective administration of MNPs in hyperthermia, they need to show high heating attributes under physiological safe values of the field, frequency, and for a minimal amount of material. In this regard, an attempt has been made to synthesize MnFe2O4 nanoparticles and functionalize them with the biocompatible polyvinylpyrrolidone (PVP) polymer. Functionalized nanoparticles are characterized for magneto-structural and morphological analysis. The heating capacity of MNPs is contemplated to evaluate the attainability to use in hyperthermia applications. Results demonstrate that MNPs exhibited superparamagnetism with high magnetization at room temperature. Maximum specific absorption rate (SAR) 468.37 W g−1 has been observed at 335.2 Oe (and frequency 265 kHz) for PVP coated nanoparticles for 5 mg mL−1 concentration. Cell viability of PVP functionalized nanoparticles performed using the L929 cell line showed that the nanoparticles are biocompatible. The PVP-functionalized MnFe2O4 nanoparticles synthesized by the one-pot polyol method can be used as a heating mediator in magnetic hyperthermia therapy.