Abstract
Keeping in view the therapeutic importance of dietary fiber azadiracta indica gum in anti-inflammatory action, in the present work, gum has been modified to develop the drug delivery carrier for methyl prednisolone used for treatment of inflammatory colonic ailments to enhance its potential. Hydrogels were formed gum polysaccharide by modified by grafting and crosslinking method. Polymers were characterized by cryo-SEM, AFM, FTIR, and 13C-NMR. The cryo-SEM images confirmed the porous network structure of the hydrogels. The results showed that porosity and crosslinking density of hydrogels were influenced by the content of the monomer AAc and crosslinker NNMBA. The polymeric gels were found to have non-haemolytic (haemolytic index = 3.36 ± 1.20%), and antioxidant nature (DPPH radical scavenging = 76.88 ± 10.16%). The gel strength of the gels was 9.41 ± 0.46 Nmm. The release of methyl prednisolone was found with non-Fickian diffusion mechanism. Overall, gum based hydrogels were pH responsive and could be explored to design of colon drug delivery system for colonic ailments .
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