Abstract
In order to control multiple biological cells using holographic optical tweezers, a multi-agent cooperative controller was designed based on RBF neural network. According to analyzing the dynamic model of optical tweezers capturing cells, the position of optical trap and the distance of cell position should be controlled to avoid the cell escaping from the optical trap, thereby controlling the track tracking of single cell. On this basis, the RBF neural network controller was designed. The cell position error was taken as the controller input, and the controller output the ideal optical trap position to control cell movement. The holographic optical tweezers can be used to control multiple cells. The simulation results show that the designed RBF neural network controller can realize control the cooperative and consistent movement of multiple yeast cells on the set trajectory.
Published Version
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