Design of a high-throughput integrated microfluidic chip combining micromixing and particle sorting functions

Abstract

Most of the current microfluidic chips can only achieve a single function, such as sample mixing, particle sorting, etc. Based on this, in this paper, we designed an integrated microfluidic chip that combines micromixers and separators, which can realize both sample mixing and particle sorting functions. We use software to simulate the chip’s performance and optimize its structure. The final design of the microfluidic chip consists of two parts: the micro-mixer adopts a V-shaped structure, and there are composite sidewall microstructures and contraction and expansion structures in the flow channel; in the part of the particle sorting, we use a combination of inertial sorting and microfiltration sorting. The chip can ultimately realize rapid short-range sample solution mixing and high-efficiency particle sorting within a specific flow rate, with a mixing effect of more than 94%, a sorting efficiency of up to 100%, and a sorting purity of more than 92%.