Design of 1‐(2‐pyrrolidinone)‐butane‐1,3‐dione derivatives and acetoxylation of these compound's methylene via hypervalent iodine (III)

Abstract

AbstractAn interesting synthesis method for 2‐acetate‐1‐(2‐pyrrolidinone)‐butane‐1,3‐dione compounds was developed in this work. The synthesis of these compounds was carried out in three steps. In the first step, 2‐pyrrolidone derivatives were obtained by the Friedel‐Crafts reaction in presence of Eaton's reagent. Then, ‐NH group of 2‐pyrrolidone compounds were attached acetoacetate group in presence of 2,6‐trimethyl‐4H‐1,3‐dioxin‐4‐one reagent. Lastly, 1‐(2‐pyrrolidinone)‐butane‐1,3‐dione derivatives were reacted with Pida to attach acetoxy group to these compound's methylene.