Design, formulation, optimization and evaluation of sustained release tablets of domperidone

Abstract

Domperidone is widely used in the management of gastric disorders, particularly gastro esophageal reflux disorder and peptic ulcer. But the short half-life of domperidone leads to poor compliance and adverse reactions; that is why domperidone in sustained release dosage form is needed to achieve better therapeutic effects and to improve patient compliance. For this purpose sustained release tablets of domperidone were manufactured using different polymers, including hydroxylpropylmethylcellulose (HPMC) K100LV, hydroxylpropylcellulose (HPC) K100M and ethocel (EC-22). The prepared tablets were evaluated for their physical parameters, that is, weight variation was determined with the help of electronic balance, hardness by Monsanto tester, thickness by Vernier caliper and friability of the prepared tablets were determined with the help of Erweka friabilator and drug content was determined by UV/Visible spectrophotometer. The in vitro release studies were carried out for all the formulations of the model drug in a buffer solution of pH 6.8 and 0.1 N HCl solution. The results obtained were analyzed by different pharmacokinetic models, such as zero order, first order, Higuchi model, Hixson-Crowell cube root law and Korsmeyer-Peppas model. All the materials used were available in the local market, so we could be able to minimize the per oral cast of the formulation and also improve the patient compliance by reducing the frequency of dosing, reduce relapse and improve therapeutic outcome. Key words: Domperidone, sustained release tablets, compliance, polymers.