Abstract
Cefaclor is a second generation cephalosporin antibiotics chemically related to penicillin widely used in treatment of respiratory, urinary and skin infections most affective against gram negative organism. The objective of this work is to retardant polymers were employed with varying concentrations and also in combination in different ratio to get promising concentration for extended release matrix tablets. Matrix tablets of cefaclor were formulated using hydrophilic swellable polymers HPMC E-15 and HPMC K-100M with lactose as diluents. LHPC, Colliodal silicon dioxide, Talc, Mg. stearate and Crosscarmelose sodium were used as excipients. All the formulations prepared were found to comply with the weight variation, friability, drug content uniformity and in-vitro dissolution studies.
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