Design, Development And Evaluation Of Transdermal Drug Delivery System For Treatment Of Diabetes

Abstract

The current research aims to formulate and evaluated Cinnamaldehyde transdermal patches to treat diabetes. A good penetration enhancer Oleic Acid, would improve drug delivery from various polymer-based transdermal patches. Transdermal patches of the matrix type were made by solvent casting techniques using various polymer PVP K30, HPMC K100, and solvent. All prepared formulations were tested for folding endurance, weight variation, thickness, drug content, moisture content, moisture loss, in vitro drug release and In- vivo studies. Batch TDP1 was optimised formula from all formulation batches shows zero order release for 24 hours, with a cumulative percentage of drug diffusion of 97.68% from 2cm2 patches. It has been determined that polymer concentration HPMC films showed better release which may be attributed to the reason of high water vapour permeability of HPMC films for enhancing diffusion rate of drug through rat skin, oleic acid were incorporated as permeation enhancers in the HPMC films since they showed better release. It allows for controlled drug release from the patch. Drug content of the patches was found to be more than 98%. Variations in flux and Diffusion Coefficient were observed among various formulations. The drug–polymer interaction results suggested no interaction between drug and polymers. The in vivo results revealed that the patches successfully prevented the hyperglycaemia and they were also effective on chronic application. The transdermal route exhibited negligible skin irritation and produced better improvement with all the tested in vivo parameters compared to oral administration.