Abstract
The aim of this study is to hasten and improve the wound healing activity. Ensuring the physicochemical compatibility Glycyrrhiza glabra root Extract impregnated collagen and crosslinked collagen scaffolds (GGEICDS & GGEICCDS) were formulated using different concentrations.The formulated scaffolds were subjected to physical, biochemical and histopathological examinations. Wound healing studies on Male Wister Rats were performed for a period of 7 days and it was observed that the 10%w/v of both GGEICDS and GGEICCDS treated rats possessed higher amount of hydroxyl proline content 68.8% & 70.0 % when compared to that of the existing Marketed formulation (Neu- skinTM) (60.7%) . Further better wound healing activity was observed in the 10%w/v GGEICDS& GGEICCDS treated rats (75% & 76%). When examined histopathologically, more production in the collagen content was clearly observed in 10% w/v GGEICDS treated groups which resulted in the epithelial gap reduction. The more count of fibroblast's (62 and 64 in 100? in the wound healing process) in 10% GGEICDS and GGEICCDS treated groups was observed.
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