Abstract
A simple optical fiber sensor based on localized surface plasmon resonance was constructed for direct and rapid measurement of thyroglobulin (Tg). Specific tests for Tg in patients that have undergone thyroidectomy are limited because of insufficient sensitivity, complicated procedures, and in some cases, a long time to yield a result. A sensitive, fast, and simple method is necessary to relieve the psychological and physical burden of the patient. Various concentrations of Tg were measured in a microfluidic channel using an optical fiber sensor with gold nanoparticles. The sensor chip has a detection limit of 93.11 fg/mL with no specificity for other antigens. The potential applicability of the Tg sensing system was evaluated using arbitrary samples containing specific concentrations of Tg. Finally, the sensor can be employed to detect Tg in the patient’s serum, with a good correlation when compared with the commercial kit.
Highlights
A simple optical fiber sensor based on localized surface plasmon resonance was constructed for direct and rapid measurement of thyroglobulin (Tg)
Fiber optic Localized surface plasmon resonance (LSPR) (FO LSPR) sensors have been developed by immobilizing nanoparticles on optical fiber, based on a simple optical set-up[14,15]; this has the potential of rapid detection, low-cost, portability, and simplicity when applied to Tg sensing
An fiber optic LSPR (FO LSPR) sensor chip is proposed by immobilizing gold nanoparticles (AuNPs) on an optical fiber and combining it with a microfluidic channel (MFC) that provides a continuous fluid without exposing it to the external environment
Summary
A simple optical fiber sensor based on localized surface plasmon resonance was constructed for direct and rapid measurement of thyroglobulin (Tg). The potential applicability of the Tg sensing system was evaluated using arbitrary samples containing specific concentrations of Tg. the sensor can be employed to detect Tg in the patient’s serum, with a good correlation when compared with the commercial kit. Fiber optic LSPR (FO LSPR) sensors have been developed by immobilizing nanoparticles on optical fiber, based on a simple optical set-up[14,15]; this has the potential of rapid detection, low-cost, portability, and simplicity when applied to Tg sensing. The developed sensors exhibited a high correlation with the devices used in the clinical field These results show that our sensor can be a helpful tool for the early evaluation of the recurrence of thyroid cancer through sensitive and quick sensing of Tg in patients that undergo total thyroidectomy
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