Design and synthesis of heterocyclic Compounds from 1,4-diacetylbenzene with Expected Antimicrobial Activity

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In this present work, synthesized a novel derivatives of bis-chalcones via condensation of 1,4-diacetylbenzene with different aldehydes in basic media. The reaction of chalcone derivatives 3a,b with thioglycolic acid gave compounds 4a,b. That was reacted with ethyl cyanoacetate in presence of ammonium acetate to give the corresponding cyanopyridine derivatives 5a,b. Furthermore, bis-chalcone 3a,b was cyclization to pyrazole analogs by using 2,4-dinitrophenylhydrazine to give compounds 7a,b in good yields. All products were characterized by IR spectrum, 1HNMR, 13CNMR, and elemental analysis. The new compounds have been screened as anti-bacterial activity