Abstract
Abstract Two double-headed nucleosides,4′-C-[4-(Thymin-1-ylmethyl)-1,2,3-triazol-1-ylmethyl]thymidine and 4′-C-[4-(6N-Dibenzoyl-9-ylmethyl)-1,2,3-triazol-1-ylmethyl]thymidine were synthesized from 2ʹ-deoxythymidine as starting material by using the copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. These double-headed nucleosides could be promising nucleic acid analogs with the ability of forming new nucleic acid motifs to target the various nucleic acid structures.
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