Abstract
Series of carbamate and thiocarbamate derivatives were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Several thoicarbamate derivatives revealed promising inhibitory activity. The structure–activity relationship study of these compounds is also reported. Among these compounds, compound 12b was the most potent with 6.5μM of IC50. They inhibited NO production through the suppression of iNOS protein and mRNA expression and nuclear translocation of p65.
Full Text
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call