Abstract
Core histone is composed of two H2A-H2B dimers and H3-H4 tetramers. Each histone have tail domain, which regulates dynamic structure of chromatin and transcription through posttranslational modifications. Histone acetylation-deacetylation is one of such epigenetic regulations of gene expression in eukaryotes. Histone deacetylase (HDAC) catalyze deacetylation of lysine residues in N-terminal domain of core histones and regulates gene transcription and expression. Inhibition of HDAC induces transcriptionally active chromatin, causing arrest of growth, differentiation and apoptosis.
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