Abstract
In search of new antimycotic agents acting as ergosterol biosynthesis inhibitors we investigated widely new and optimized reaction pathways for preparing different types of triazasteroids [1, 2]. The various mono-, bi-, tri- and tetracyclic triazasteroidal compounds are designed as stable aza-analogues of carbo-cationic high energy intermediates (HEIA) of fungal enzymes [1, 2].
Highlights
In search of new antimycotic agents acting as ergosterol biosynthesis inhibitors we investigated widely new and optimized reaction pathways for preparing different types of triazasteroids [1, 2]
The various mono, bi, tri- and tetracyclic triazasteroidal compounds are designed as stable aza-analogues of carbocationic high energy intermediates (HEIA) of fungal enzymes [1, 2]
Acetoxy-25,26,27-trinor-8-lanosten-24-oyl azide (3b) was converted in better yield via Curtius rearrangement in the presence of water to yield amine 4
Summary
In search of new antimycotic agents acting as ergosterol biosynthesis inhibitors we investigated widely new and optimized reaction pathways for preparing different types of triazasteroids [1, 2]. The various mono-, bi-, tri- and tetracyclic triazasteroidal compounds are designed as stable aza-analogues of carbocationic high energy intermediates (HEIA) of fungal enzymes [1, 2].
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