Abstract
Here we reported the synthesis, radiolabeling and evaluation of a novel positron emission tomography (PET) tracer DOTA-Benerotide labeled with 68Ga with potential application in SSTR1,2,3,5 positive tumors for PET imaging. Radiolabeling of DOTA-Benerotide with 68Ga achieved its highest efficiency at pH 3.5 and 100 °C for 20 min. It also showed excellent in vitro stability in different buffers. Micro-PET imaging of human colorectal adenocarcinoma tumor cell (HT-29) bearing mice clearly delineated tumors at 4 h after tail vein injection of 68Ga-DOTA-Benerotide tracer. Further studies are needed to identify the mechanism of cell/organ uptake of this new SSTR PET imaging tracer.
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