Abstract

Objective: The objective of the study is to explore polysaccharide mucilages of Colocasia esculenta (CE), and Fenugreek (FG) as buoyancy enhancing agents, and mucoadhesive agents by developing gastroretentive floating tablets of Glipizide.
 Methods: Glipizide loaded floating tablets were developed with CE, and FG alone and in combination of Guar gum (GG), and Hydroxypropyl methylcellulose (HPMC) K4M using direct compression technique. The developed formulations have been subjected to evaluation of in vitro buoyancy study, in vitro drug release study (pH 1.2), and in vitro bioadhesiveness study. Therefore, the final optimized formulation was subjected to Fourier Transform Infrared Spectroscopy (FTIR), Differential scanning calorimetry (DSC), and X-ray powder diffraction (XRD) study.
 Results: The results of the buoyancy study for formulation F1, F2, and F5 revealed that the instant floating lag time, floating time duration of 1 h, and exhibited 100% drug release in 4 h. Therefore, the formulations developed with GG (F3), and HPMC K4M (F4) have been exhibited slow floating lag time, prolonged floating duration and drug released up to 100 % in 12 h, while; formulations F6, F7, F8, and F9 have been exhibited shortest floating lag time, longest floating time duration, the best drug released up to 12 h, and better in vitro bioadhesiveness properties. Furthermore, F7 exhibited good bioadhesive property as compared to F6, F8-F9. The results of the FTIR, DSC, and XRD study for F7 revealed that the presence of functional groups and amorphous.
 Conclusion: Owing to the anticipated properties like biocompatibility, biodegradability, swelling ability, and cost-effectiveness of CE; it could be the potential macromolecule for the replacement of synthetic polymers.

Highlights

  • Natural powdered extracts are acquired from vegetable sources with high molecular weight uronic acid and sugar units [1]

  • The main objective of the present study is to develop mucoadhesive, swellable, floating Gastroretentive drug delivery system (GRDDS) by using Colocasia esculenta (CE), FG, Guar gum (GG), and Hydroxypropyl methylcellulose (HPMC) K4M alone and in combination to improve gastric retention by lowering the floating lag time, and enhancing the floating duration with sustained drug release profiles and mucoadhesive property of Glipizide loaded GRDDS

  • Mucoadhesive, floating, and sustainedrelease tablets of Glipizide developed by using CE(F1), FG(F2),GG(3), HPMC K4M(F4) alone and in combination with CE+FG(F5), CE+GG(F6), CE+HPMC K4M(F7), FG+GG(F8) and FG+HPMC K4M(F9)

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Summary

Introduction

Natural powdered extracts are acquired from vegetable sources with high molecular weight uronic acid and sugar units [1]. Numerous types of approaches have been reported for development of GRDDS which include; floating systems, bioadhesive systems, hydrodynamically balanced systems, swelling, and expanding systems to enhance the gastric residence time [20, 21]. These dosage forms are very effective, when the fluid level in the stomach is sufficiently high. It can be restrained by developing the formulation and it may be required to attach the mucous membrane of the stomach wall

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