Design and Evaluation of Novel Oro-Dispersible Sustained Release Tablets of Poly Ethylene Glycol based Solid Dispersion of Domperidone

Abstract

Solid dispersion has been widely used as cost efficient solubility enhancement technique for poorly water-soluble drugs. Domperidone (DOM) is practically insoluble in water which resulted in its poor oral bioavailability. Solid dispersion of DOM with poly ethylene glycol 4000 (PEG) in 1:3 was prepared by melting method to improve solubility of DOM. Solid dispersions were characterized by FTIR, DSC and XRD techniques. Further solid dispersion of DOM was treated with molten lipid to form solid dispersion based sustained release (SDSR) granules. The integrity of solid dispersion in SDSR granules was also investigated by XRD studies. Drug release from SDSR granules was sustained up to 12 hrs. Finally, orodispersible (OD-SDSR) tablet of SDSR granules were prepared in order to improve patient compliance. The optimum formulation was rapidly disintegrated within 40 seconds.