Abstract
Objective: The main objective of the current research is focused in discovering the best polyethylene glycol (PEG) as solid dispersion carrier using etoricoxib (ECB) as a model drug.
 Methods: Varieties of PEG, namely PEG - 3350, PEG - 4000, PEG - 6000, PEG - 8000, and PEG - 20000, were evaluated as a carrier for making ECB solid dispersions. ECB:PEG was taken in the ratios of 1:1, 1:2, 1:4, and 1:6. The solid dispersions were prepared by microwave fusion method and compressed using 8 station tablet compression machine. The fabricated solid dispersion tablets were tested for physicochemical characteristics and drug release rates. The release of ECB from the prepared solid dispersions was further analyzed kinetically using the first order and Hixson-Crowell’s plots.
 Results: All the solid dispersion batches were shown satisfactory physicochemical characteristics. ECB solid dispersion batches with PEG - 6000 showed good solubility in distilled water (up to 2.29±0.01 μg/ml) and in 0.1 N HCl (up to 2.18±0.01 μg/ml) when compared with ECB alone (0.21±0.01 μg/ml and 0.32±0.01 μg/ml). The prepared solid dispersions with PEG 6000 are shown good ECB release.
 Conclusion: Among PEG carriers, PEG - 6000 was found to be the best carrier for increasing the solubility and release rate of ECB form the solid dispersions compared to PEG - 3350, PEG - 4000, PEG - 8000, and PEG - 20000.
Highlights
The industrial pharmacist makes so many trials with the aim to increase the solubility of poorly water-soluble drugs in an inexpensive way
Etoricoxib (ECB) is a nonsteroidal drug used in dealing with all the varieties of pain and arthritic inflammation
The present exploration was to increase the solubility of ECB by making solid dispersions using polyethylene glycol (PEG) carriers [4,5,6,7,8], namely PEG - 3350, PEG - 4000, PEG - 6000, PEG - 8000, and PEG - 20000 and finding out the best polymer among them
Summary
The industrial pharmacist makes so many trials with the aim to increase the solubility of poorly water-soluble drugs in an inexpensive way. Among the different techniques of increasing solubility, solid dispersion technique was attaining the fame [1]. Etoricoxib (ECB) is a nonsteroidal drug used in dealing with all the varieties of pain and arthritic inflammation. ECB is a poorly watersoluble drug with 92% protein binding and poor bioavailability [2,3]. The present exploration was to increase the solubility of ECB by making solid dispersions using polyethylene glycol (PEG) carriers [4,5,6,7,8], namely PEG - 3350, PEG - 4000, PEG - 6000, PEG - 8000, and PEG - 20000 and finding out the best polymer among them.
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More From: Asian Journal of Pharmaceutical and Clinical Research
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