Abstract
Floating drug delivery system is one of the novel drug delivery system. Floating drug delivery system such as microspheres have a bulk density less than gastric fluids and thus it remains buoyant in the stomach and thus it remains buoyant on stomach content for long time in the drug releasing process. Hence it is useful for obtaining sufficient bioavailability for long time and effective plasma level. Microspheres provide a constant & prolonged therapeutic effect which will reduce dosing frequency. Ketoprofen is a nonsteroidal anti-inflammatory drug with well established analgesic and antiarthritic effect by inhibiting the prostaglandin and leukotriene synthesis. It is widely used for the treatment of arthritis related disorders such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. But it requires frequent administration to maintain the plasma drug concentration as the half life of the drug is less and when administered orally. The short half-life and the low single administration dose make ketoprofen a very good candidate for the formulation of controlled release dosage forms such as microspheres. It was also reported that microspheres of nonsteroidal anti-inflammatory drug, reduce gastrointestinal tract irritation. Keywords: Floating drug delivery system, microspheres, Ketoprofen, rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis
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