Abstract
Background: Drug delivery systems based on microballoons are one of the promising approaches for gastric retention, especially useful for drugs with site-specific absorption in the stomach. The microballoons are hollow, spherical particles under 200 micrometers, designed to float in the gastric environment. The Aceclofenac formulation of an NSAID is helpful with a half-life of 4–4.3 hours; this delivery form gives a sustained release and maintains constant plasma levels with enhanced bioavailability and decrease in dosing frequency. Methodology: Microballoons of Aceclofenac were prepared using Eudragit RS 100 and Hydroxy Propyl Methyl Cellulose as polymers from the emulsion–solvent diffusion method. In this, the polymers impart stability along with a profile of controlled release. Here, the microballoons was evaluated for physical parameter and the release profile regarding average particle size, floatation percentage, entrapment efficiency, true tapped density, and percentage yield, and FTIR will be carried out on complexes of drug and polymer. Results and Discussion: The prepared microballoons exhibit excellent floating properties and uniformity in size, which aided in long gastric retention. High entrapment efficiency with controlled and sustained release of the drug for an extended period was obtained. FTIR studies indicated that Aceclofenac remained stable in the polymer matrix with no considerable chemical interaction between the drug and the polymers. Conclusion: This research shows promise in microballoons-based delivery systems that could maintain the release for a longer duration from the delivery device with respect to Aceclofenac, which enhances bioavailability and reduces dosing frequencies. Keywords: Aceclofenac, Microballoons, NSAID, Sustain Release Medication, Eudragit RS100, HPMC
Published Version
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