Design and Analysis of Microchannel for Plasma Separation from Blood

Abstract

Microchannel device is important and having great use in field of biological research. The micro channels having some advantages like reduction in the sample processing time, consumption of costly reagents and sample volumes. The current work for microchannel is based on the Zwiefach- fung bifurcation law which used to study for separation process. The microchannel based plasma separation is far better and rapid than conventional plasma separation techniques like centrifugation, filtration. Microchannel flow simulation is carried out using CFD software. The analysis is done for different type channel with combination of various sets of different shape and size of obstacles placed along the channel walls. For this analysis we used computational fluid dynamic tool known as COMSOL MULTIPHYSICS 5.0, to study different configurations on pressure and velocity drop. Also, the effect of geometry, cross sectional area are studied. While analysis different obstacles placed along the channel like rectangular, semicircle and triangular are used. The analysis is done for each shape obstacle and observation are recorded while analysis it is observed of that pressure is decreases with increase in number of obstacles.