Abstract
The main component of human health is nutrition which becomes even more important if a person is sick. In the body of cancer patients metabolic processes change, so he/she requires a special diet. Probiotics and short peptides are the integral part of the diet of cancer patients. One of the goals of nutritional support for cancer patients is the visceral protein pool maintenance. In modern formulae for enteral support for cancer patients the protein component can be represented in one of three types: native protein; cow’s milk whey/whole protein peptides; free amino acids. The present article deals with study on biotechnological treatment influence on milk protein controlled hydrolysis process with the aim of deriving biologically active peptides, as well as of studying several qualities: immunomodulatory, cytotoxic, antioxidant and prebiotic. Conditions for enzymic hydrolysis of milk proteins are optimised, which provide deriving biologically active directional peptides. The optimal parameters of hydrolysis conduction are chosen, which provide the polypeptide chain division into peptides and free amino acids, as well as enzymic system was chosen, consisting of chymotrypsin or thermolysin at a temperature of 37±2°C, in the enzyme-substrate ratio of 1 to 50 and process time of 12.00±0.05 h. The qualities of biologically active peptides (immunomodulatory, cytotoxic, antioxidant and prebiotic), derived from milk proteins, are studied. The studies demonstrated that all peptides under study have anti-tumour qualities, at the same time increase in biopeptide concentration causes decrease in the capacity for survival of different line cancer cells
Highlights
The healthy and balanced foodstuff industrial production is one of the most important problems faced by humankind
Enzymic hydrolysis is conducted under the following parameters: temperature of 37+2oС, duration 8.00±0.05 h, рН 7.5±0,1 h, enzyme-substrate ratio of 1 to 50
About two decades ago it became known that milk proteins are the main source of biologically active peptides
Summary
The healthy and balanced foodstuff industrial production is one of the most important problems faced by humankind. In the modern Russia under the conditions of difficult demographic situation, elaboration of efficient and cost-effective approaches to the accelerated population recovery is becoming one of the scientific and applied areas of highest priority, which is specified in «Koncepciya gosudarstvennoi politiki v oblasti zdorovogo pitaniia naseleniia Rossii na period do 2020 goda» [the Public Policy Concept in the sphere of healthy nutrition of the Russian population up to 2020], approved by the government. In recent years the concept of human symbiotic microbiota participation in maintenance of human health and in the occurrence of many diseases is becoming more popular [23]. In this area the main objective of the studies is to work out functional foodstuffs for nutritional support for cancer patients during rehabilitation period
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