Abstract
Dithiols and certain monothiols reacted with phenylarsine oxide to give derivatives suitable for gas chromatography. Dihydrolipoic acid (6,8-dimercapto- n-octanoic acid) was thus determined after derivatization of the dithiol moiety to a dithiarsolane followed by extractive alkylation of the carboxyl group to the benzyl ester. 2,3-Dimercapto-1-propanol was converted into a dithiarsane, whereas bioxatriarsolane derivatives were obtained from dithiothreitol and dithioerythritol (the threo and erythro isomers of 1,4-dimercapto-2,3-butanediol) as each thiol group and its adjacent hydroxyl group in these compounds reacted with the arsenical. Mercaptoethanol and mercaptoacetic acid were also successfully derivatives for gas chromatography with phenylarsine oxide but α-toluenethiol and 1-dodecanethiol were not.
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