Deregulation of the c-myc and N-myc genes in transformed cells.

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Expression of the c-myc proto-oncogene is regulated by mitogens in a number of cell types, including fibroblasts and lymphoid cells. In growth arrested fibroblasts, serum, epidermal growth factor, or platelet derived growth factor are all capable of inducing c-myc mRNA (Campisi et al., 1984; Kelly et al.,1983). The mechanism of this induction appears to require either protein kinase C- or protein kinase A-dependent events (Ran et al., 1986). We have begun to examine these events in greater detail by studying fibroblasts showing de-regulated c-myc expression and myeloid cells containing exogenously introduced c-myc constructs.