DERAJAT DISPLASIA EPITEL PADA LIDAH YANG DIINDUKSI CANDIDA ALBICANS DENGAN KONDISI IMUNOSUPRESI

Abstract

Background: C andida albicans is a common opportunistic pathogen that play a significant role in oral candidiasis and mucosal carcinogenesis. Several studies founding that Candida sp. associated with dysplastic alteration in the epithelium . Candida present in oral cavity with epithelial change is one of predisposing factor of candida infection and lead to atypia to dysplasia. Immunosupression condition is predisposition factor of oral candidal infection. P urpose: To investigate the degree of epithelial dysplasia in tounge induced by Candida albicans in immunosuppred condition . Method: This study was true experimental with posttest-only control group design. Sixteen healthy male Rattus novergicus (Wistar), 12 weeks and 200-250 g weight, were immunosuppressed through oral administration of dexamethasone and tetracycline for 21 days and induced with C.albicans (ATCC-10231) 1-Mc.Farland. The subjects were divided into 4 groups (n=4/group): healthy (H G ), immunosuppressed (IG), Immunosupressed+Candida Albicans (ICG), and nystatin treatment(N G ). The subjects were treated for 14 days, later the rats were euthanized and their tongue being biopsied. Epithelial dysplasia was subjected to HE examination, observed under a microscope (400x magnification) and statistically analyzed (Kruskall wallis, Mann withey, p 0.05) . Conclusion : There was epithelial change in the tongue both in immunosupressed condition with or without induction Candida albicans. Degree of epithelial dysplasia in tounge induced by Candida albicans in immunosupre sse d condition group was the heaviest than other group . Keywords: epithelial dysplasia , immunosuppressed condition , oral candidiasis