Der einfluss möglicher adrenalinvorstufen auf die ausscheidung von adrenalin im harn von ratten

Abstract

Using a fluorometric determination the urinary content of epinephrine in normal and 1-DOPA resp. HOT treated rats was investigated. The following results could be obtained: (1) In normal rats the 24 hr urinary output was of the order of 1 μg. (2) Daily administration of 100 μg Methyldihydroxyphenylserine (MDOPS), or of 10 mg 1-DOPA and HOT respectively did not cause any change in the 24 hr urinary epinephrine output. In a second series of experiments the urinary excretion of subcutaneously administered epinephrine was investigated in rats. It was found that following the injection of 50 μg to 400 μg epinephrine/animal, 4–5 per cent of the injected epinephrine was recovered in the urine. The percentage of the urinary excretion of epinephrine was independant of the dosage and was not altered by repeated administration of epinephrine (every 6th day) to the same animal group throughout a period of fifty days. Daily treatment with 10 mg 1-DOPA per animal did not lead to a significant change of the urinary excretion of subcutaneously administered epinephrine. However the daily administration of 10 mg HOT per animal produced a slight decrease in the urinary recoveries of injected epinephrine.