Abstract
Aim. To study the effect of substance P on the blood serum glycoproteins in experimental animals with different stress-resistance profiles under technogenic rotating electric field.
 Methods. The level of sialic acids, mucoproteins, fucose, and -L-fucosidase was determined in the blood serum of 72 noninbred white male rats before (control) and on the 10th and 20th day of exposure to a technogenic rotating electric field (REF), as well as under the combination of technogenic rotating electric field and substance P injection at the same time. To determine the stress resistance, the animals were tested using the open field method. Animals were divided into groups based on the tests data obtained: stress-resistant, not stress-resistant and ambivalent.
 Results. On the 10th day of technogenic rotating electric field action, the level of sialic acids, fucose, and -L-fucosidase activity increased in all animals. The concentration of mucoproteins tended to decrease. On the 20th day, the sialic acids content remained elevated compared with the control in all groups. The content of mucoproteins decreased in stress-resistant, not stress-resistant and restored to the control level in ambivalent compared with those on the 10th day. On the 20th day, fucose concentration reached control values in stress-resistant and ambivalent animals and decreased in not stress-resistant. On the 10th day of the combined exposure, the concentration of sialic acids, mucoproteins, fucose, -L-fucosidase was reduced in all animals compared with the 10th day of technogenic rotating electric field action. On the 20th day of the combined exposure, the values of the studied parameters remained reduced in all groups of animals compared with those on the 20th day of isolated technogenic rotating electric field action.
 Conclusion. The substance P injection limits the effects of technogenic rotating electric field on the metabolism of carbohydrate-containing biopolymers in blood serum in all groups of animals, as can be seen by a decrease in the level of sialic acids, fucose, and low enzymatic activity of -L-fucosidase under combined exposure.
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