Deproteinised calf blood extract eye gel and sodium hyaluronate eye drops in meibomian gland related dry eye

Abstract

Objective To evaluate the clinic efficacy between deproteinised calf blood extract eye gel and sodium hyaluronate eye drops on recovery of meibomian gland related dry eye,to provide reference for drug treatment of meibomian gland related dry eye.Methods A randomized comparative study of deproteinised calf blood extract eye gel versus sodium hyaluronate eye drops both four times per day on a total of 80 patients (40 patients each group) with meibomian gland related dry eye.Both groups received applications of eyelid margins cleansing,eyelids warm compresses and massage,erythromycin ointment every night as side treatment.Symptom scores,Schirmer test values,tear film break-up times (BUT),fluorescein staining scores,meibo-scores were recorded on the last day before treatment and 30±7 day after start of treatment.Results The symptom scores of pre-and post-treatment in patients with deproteinised calf blood extract eye gel were,14.23±4.64,5.95±2.87; BUT scores 3.28±2.67,5.80±3.05; and fluorescein staining scores 3.71±3.84,1.83±1.535.10±2.416 score,which reached a significant statistic difference (t =3.25,P ＜0.01).The symptom scores of pre-and post-treatment with sodium hyaluronate eye drops were 13.05±2.14,7.83±2.24;and BUT scores 3.63±2.64,4.89±2.35 which had a statistic difference (t =2.97,P ＜0.05).Meibo-scores pre-and post-treatment in deproteinised calf blood extract eye gel group and sodium hyaluronate eye drops group were 3.95±1.19 score,3.88±l.43score; 3.93±1.25 score,3.98±1.33 score with no statistic difference in groups (t =3.42,P ＞0.05).Between the two groups,there were significant statistic difference in symptom (t =3.42,P ＜0.01),the change of BUTs (t =-2.52,P ＜0.05) and fluorescein staining scores (t =3.268,P ＜0.01),however the change of meibo-scores had no statistic difference (t =0.537,P＞0.05).Conclusions Topical application of deproteinised calf blood extract eye gel and sodium hyaluronate eye drops both have a clearly beneficial effect on subjective symptoms and BUT in meibomian gland related dry eye.Deproteinised calf blood extract eye gel have more powerful effect on BUT and superficial punctuate keratopathy.However application of the both drugs alone cannot recover meibomian glands condition in dry eye patients. Key words: Deproteinised calf blood extract eye gel; Dry eye; Meibomian gland; Noncontact meibography system