Comparison of autologous serum eye drops and deproteinized calf blood extract eye gel for corneal repair after pterygium operation

Abstract

Objective To compare the efficacy of autologous serum eye drops and deproteinized calf blood extract eye gel for corneal repair in the treatment of pterygium surgery.Methods A total of 60 cases (60 eyes) were received pterygium resection combined with limbal-conjunctival autografting.After surgery,they were randomly assigned to autologous serum eye drops (n =30) or deproteinized calf blood extract eye gel (n =30).Corneal wound healing,the presence or absence of conjunctival proliferation and hyperemia was analyzed at 3 months postoperatively.Results Patients received autologous serum eye drops felt less foreign body sensation,pain and other symptoms on the 3rd day and only mild foreign body sensation on the 4th day.In the extract eye gel group,photophobia and lacrimation began to ease after the 4th day; the foreign body sensation apparently disappeared on the 6th day.The Mean time of corneal epithelium repair were (2.55±1.31) days in the autologous serum group and (3.55±1.23) days in the deproteinized calf blood extract eye gel group,which showed significant difference (P ＜0.05).Visual acuity between the two groups showed no significant difference (P ＞0.05).Three months after surgery,there were no significant complications associated with the use of autologous serum eye drops or deproteinized calf blood extract eye gel including infection and rejection.Conclusions Both of the autologous serum eye drops and deproteinized calf blood extract eye gel are effective for comeal repair in the treatment of pterygium.Patients undergoing autologous serum eye drops experience faster recovery,less foreign body sensation and mild discomfort compared with those undergoing deproteinized calf blood extract eye gel. Key words: Pterygium; Autologous serum; Deproteinized calf blood extract eye gel; Limbal stem cell; Transplantation