Abstract
Aim: Major depression is one of the most common psychiatric disorders, and treatment non-adherence is one of the important problems that negatively affect treatment outcomes in the treatment of depression. The aim of this study is to determine the effect of motivational interview on the treatment adherence.
 Material and Method: This study is a control group experimental research with pre-test and post-test repetitive measurements. The sampling of the study consists of 81 depressive patients, 40 experimental and 41 controls, who applied to the Psychiatry service/polyclinic of the Training and Research Hospital. The personal information form and The Morisky Medication Adherence Scale (MMAS) were used in data collection. 
 Results: As a result of the motivational interviews, the MMAS scores of the experimental group decreased to a significant level in the mid-test and post-test compared to the pre-test, and no significant difference was found in the mean scale scores of the control group without intervention (p>0.05).
 Conclusion: It has been found that motivational interviews are an effective intervention to improve medication adherence in the patients with depression. Healthcare professionals can facilitate adherence with the medical treatment regimen in depressed patients through motivational interview practices.
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