Abstract
BackgroundOxidative stress is known to be a factor in various diseases. In this study, we investigated whether physical and psychological symptoms of menopause, cardiovascular parameters, body composition, and lifestyle factors are associated with oxidative stress in middle-aged women.MethodsThis cross-sectional study used baseline data collected in a previous study that examined the effects of a dietary supplement on a variety of health parameters in 95 women aged 40 to 60 years. Participants had been assessed for age, menopausal status, body composition, cardiovascular parameters, physical and psychological symptoms of menopause, and lifestyle factors. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) level, an oxidative stress marker, had also been measured. Dichotomizing 8-OHdG levels as low (≤25 ng/mg creatinine) and high (>25 ng/mg creatinine), we sought to identify the health parameters that are associated with high 8-OHdG level.ResultsWomen with a high 8-OHdG level had lower body weight, lower body mass index, lower body fat mass, higher body temperature, scored higher for both anxiety and depression on the Hospital Anxiety and Depression Scale (HADS), and consumed more alcohol. Multiple logistic regression analysis revealed that the HADS-depression subscale (HADS-D) score was the sole independent contributor to high 8-OHdG level (adjusted odds ratio, 1.23 per point increase in HADS-D score; 95 % confidence interval, 1.06–1.45).ConclusionDepressive symptom score was shown to be independently associated with high 8-OHdG level in middle-aged women, suggesting a link between mood disorder and oxidative stress.Trial registrationUMIN-CTR UMIN000009353.
Highlights
Oxidative stress is known to be a factor in various diseases
The aim of this study was to investigate whether physical and psychological symptoms of menopause, cardiovascular parameters, body composition, and lifestyle factors are associated with oxidative stress in middle-aged women using urinary 8-OHdG level as a marker
The 95 participants were divided into two groups according to urinary 8-OHdG level: 59 women had a low level (≤25 ng/mg creatinine) and 36 had a high level (>25 ng/mg creatinine)
Summary
We investigated whether physical and psychological symptoms of menopause, cardiovascular parameters, body composition, and lifestyle factors are associated with oxidative stress in middle-aged women. Health promotion for middle-aged women is gaining attention due to the various health care issues raised with the advent of an aging society. Women in this age group are bothered by menopausal symptoms, such as hot flashes, night sweats, vaginal dryness, anxiety, depression, and insomnia, but are at increased risk for cardiovascular disease (CVD), central obesity, hypertension, dyslipidemia, and diabetes [1,2,3,4]. Oxygen is vital for all aerobic organisms. A novel automatic analyzer for competitive immunochromatography was developed, making measurement of urinary 8-OHdG level much quicker and easier than before
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