Dependence of the Most Probable and Average Bond Rupture Forces on the Force Loading Rate in Single Molecule Dynamic Force Spectroscopy Experiment: First Order Correction to the Bell - Evans Model

Abstract

The Bell-Evans model which predicts the linear dependence of the most probable bond rupture force on the logarithm of the force loading rate is usually used to discuss the dynamic force spectroscopy experiment data. This model is consistent with the Kramers' theory of the bond dissociation rate only if one presupposes an independence of the pre-exponential factors in the Kramers relation on the acting force F and a linear decrease of the dissociation barrier height on this same force, and for this to be true a rather special shape of the interaction landscape is required.